Surfactants as penetration enhancers for dermal and transdermal drug delivery
chapter
posted on 2023-06-09, 03:25 authored by Taravat Ghafourian, Ali Nokhodchi, W KaialyOwing to the specific molecular structure of surfactants, these compounds can penetrate into the stratum corneum (SC) and thereby increase the transdermal absorption of drugs. As a result, surfactants are some of the most widely used enhancers in transdermal drug delivery formulations/systems. Starting with an introduction into the chemical structure and physicochemical characteristics of surfactants, this chapter is focused on the application of various surfactants for increasing the skin absorption of drugs and the mechanisms involved in this process. In particular, application of various ionic and nonionic surfactants and synergism with physical and chemical permeation enhancement methods such as electrophoresis have been discussed, and key publications in this subject area have been introduced. © Springer-Verlag Berlin Heidelberg 2015.
History
Publication status
- Published
Journal
Percutaneous Penetration Enhancers Chemical Methods in Penetration Enhancement: Modification of the Stratum CorneumPublisher
Springer Berlin HeidelbergExternal DOI
Page range
207-230Book title
Percutaneous penetration enhancers chemical methods in penetration enhancement: Modification of the stratum corneumISBN
9783662470398Department affiliated with
- Biochemistry Publications
Full text available
- No
Peer reviewed?
- Yes
Editors
H I Maibach, N DragicevicLegacy Posted Date
2017-12-01Usage metrics
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