This article critically engages with recent efforts to frame the global AIDS pandemic as an international security issue. The securitization of HIV/AIDS is significant, the article argues, not just because it is a novel way of conceptualizing the global AIDS pandemic, but also because it marks an important contemporary site for the global dissemination of a biopolitical economy of power revolving around the government of ‘life’. This biopolitical dimension to the securitization of AIDS brings into play a set of potentially racist and normalizing social practices, which, the article argues, international political actors should seek to avoid in their attempts to find appropriate and effective responses to the global AIDS pandemic. Ways of minimizing these dangers are explored in the conclusion of the article.