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A stochastic framework of neurogenesis underlies the assembly of neocortical cytoarchitecture
Version 2 2023-06-12, 09:15
Version 1 2023-06-09, 19:45
journal contribution
posted on 2023-06-12, 09:15 authored by Alfredo Llorca, Gabriele Ciceri, Robert Beattie, Fong Kuan Wong, Giovanni Diana, Eleni Serafeimidou-Pouliou, Marian Fernández-Otero, Carmen Streicher, Sebastian J Arnold, Martin Meyer, Simon Hippenmeyer, Miguel Maravall RodriguezMiguel Maravall Rodriguez, Oscar MarinThe cerebral cortex contains multiple areas with distinctive cytoarchitectonical patterns, but the cellular mechanisms underlying the emergence of this diversity remain unclear. Here, we have investigated the neuronal output of individual progenitor cells in the developing mouse neocortex using a combination of methods that together circumvent the biases and limitations of individual approaches. Our experimental results indicate that progenitor cells generate pyramidal cell lineages with a wide range of sizes and laminar configurations. Mathematical modelling indicates that these outcomes are compatible with a stochastic model of cortical neurogenesis in which progenitor cells undergo a series of probabilistic decisions that lead to the specification of very heterogeneous progenies. Our findings support a mechanism for cortical neurogenesis whose flexibility would make it capable to generate the diverse cytoarchitectures that characterize distinct neocortical areas.
History
Publication status
- Published
File Version
- Published version
Journal
eLifeISSN
2050-084XPublisher
eLife Sciences PublicationsExternal DOI
Volume
8Page range
1-78Department affiliated with
- Neuroscience Publications
Research groups affiliated with
- Sussex Neuroscience Publications
Full text available
- Yes
Peer reviewed?
- Yes
Legacy Posted Date
2019-11-26First Open Access (FOA) Date
2019-11-26First Compliant Deposit (FCD) Date
2019-11-26Usage metrics
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