posted on 2023-06-09, 16:27authored bySayyed Saeid Khayyatzadeh, Mehrane Mehramiz, Habibollah Esmaeily, Seyed Jamal Mirmousavi, Leila Khajavi, Fatemeh Nejati Salehkhani, Parichehr Hanachi, Hamidreza Bahrami-Taghanaki, Saeed Eslami, Hasan Vatanparast, Gordon FernsGordon Ferns, Amir Avan, Majid Ghayour-Mobarhan
Aim The determinants of serum vitamin D seems to be the environmental factors (dietary and supplementary intake and exposure to ultraviolet light) and genetic factors. We aimed to study the relationship between a vitamin D-associated genetic polymorphism and serum 25(OH)D concentrations in healthy adolescent girls in Iran, and its effects on a high-dose supplement of vitamin D. Material and method A total of 616 healthy adolescent girls with mean age 15 received 50,000 IU of vitamin D3 weekly over 9 weeks. Serum vitamin D levels and other metabolic factors were measured at baseline and after the intervention. The genotyping of the CYP2R1 variant (rs10741657) was performed by TaqMan genotyping assays. Results Regardless of the genetic background, at baseline, 87% of adolescent girls were vitamin D deficient (serum 25(OH)D level?