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A versatile procedure for the generation of nucleoside 5'-carboxylic acids using nucleoside oxidase

journal contribution
posted on 2023-06-08, 19:31 authored by Mahmoud Mahmoudian, Brian A M Rudd, Brian Cox, Chris S Drake, Richard M Hall, Paul Stead, Michael J Dawson, Malcolm Chandler, David G Livermore, Nicholas J Turner, Gareth Jenkins
The nucleoside oxidase from Stenotrophomonas maltophilia (FERM BP-2252) has been used to generate 5'-carboxylic acid derivatives of nucleoside analogues. The enzyme, which has a surprisingly broad substrate specificity for unnatural nucleosides, has been immobilised and used at preparative scale.

History

Publication status

  • Published

Journal

Tetrahedron

ISSN

0040-4020

Publisher

Elsevier

External DOI

Issue

28

Volume

54

Page range

8171-8182

Department affiliated with

  • Chemistry Publications

Full text available

  • No

Peer reviewed?

  • Yes

Legacy Posted Date

2015-01-13

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    University of Sussex (Publications)

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