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Abnormal whole-brain functional connection in amnestic mild cognitive impairment patients
journal contribution
posted on 2023-06-09, 03:03 authored by Feng Baia, Wei Liaoc, David R Watson, Yongmei Shib, Yi Wanga, Chunxian Yuea, Yuhuan Tenga, Di Wu, Yuanb Yonggui, Jia Jianping, Zhanga ZhijunAmnestic mild cognitive impairment (aMCI) patients are thought to be particularly vulnerable to convert to clinical AD where functional disconnection is a major feature of the cortical neuropathology. However, the presence and extent of whole-brain connectivity disturbances is largely unknown in aMCI patients. Twenty-six aMCI patients and eighteen matched healthy subjects were evaluated at baseline and at mean 20 months follow up. Temporal correlations between spatially distinct regions were evaluated by using longitudinal resting-state fMRI. Compared to normal aging controls, patterns of abnormal interregional correlations in widely dispersed brain areas were identified in the patients, which also changed with disease progression. These disturbances were found particularly in subcortical regions and frontal cortex. Importantly, significantly decreased negative functional connection may be specifically associated with the development of aMCI patients. This suggests a compensatory mechanism is underway where local processing deficits are offset by recruitment of more dispersed cortical regions. In addition, the presence of this increased connectivity is seen to eventually weaken with disease progression. The results suggest that patterns of whole-brain functional connection may be a useful risk marker for conversion to AD in aMCI patients.
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Publication status
- Published
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- Published version
Journal
Behavioural Brain ResearchISSN
0166-4328Publisher
ElsevierExternal DOI
Issue
2Volume
216Page range
666 -672Department affiliated with
- BSMS Neuroscience Publications
Full text available
- No
Peer reviewed?
- Yes
Legacy Posted Date
2016-10-03First Compliant Deposit (FCD) Date
2016-10-03Usage metrics
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