CastellanoMBE16.pdf (754.17 kB)
Adaptive evolution is substantially impeded by Hill–Robertson interference in Drosophila
journal contribution
posted on 2023-06-09, 00:00 authored by David Castellano, Marta Coronado-Zamora, Jose L Campos, Antonio Barbadilla, Adam Eyre-WalkerAdam Eyre-WalkerHill–Robertson interference (HRi) is expected to reduce the efficiency of natural selection when two or more linked selected sites do not segregate freely, but no attempt has been done so far to quantify the overall impact of HRi on the rate of adaptive evolution for any given genome. In this work, we estimate how much HRi impedes the rate of adaptive evolution in the coding genome of Drosophila melanogaster. We compiled a data set of 6,141 autosomal protein-coding genes from Drosophila, from which polymorphism levels in D. melanogaster and divergence out to D. yakuba were estimated. The rate of adaptive evolution was calculated using a derivative of the McDonald–Kreitman test that controls for slightly deleterious mutations. We find that the rate of adaptive amino acid substitution at a given position of the genome is positively correlated to both the rate of recombination and the mutation rate, and negatively correlated to the gene density of the region. These correlations are robust to controlling for each other, for synonymous codon bias and for gene functions related to immune response and testes. We show that HRi diminishes the rate of adaptive evolution by approximately 27%. Interestingly, genes with low mutation rates embedded in gene poor regions lose approximately 17% of their adaptive substitutions whereas genes with high mutation rates embedded in gene rich regions lose approximately 60%. We conclude that HRi hampers the rate of adaptive evolution in Drosophila and that the variation in recombination, mutation, and gene density along the genome affects the HRi effect.
History
Publication status
- Published
File Version
- Published version
Journal
Molecular Biology and EvolutionISSN
0737-4038Publisher
Oxford University PressExternal DOI
Issue
2Volume
33Page range
442-455Department affiliated with
- Evolution, Behaviour and Environment Publications
Full text available
- Yes
Peer reviewed?
- Yes
Legacy Posted Date
2016-01-15First Open Access (FOA) Date
2016-01-15First Compliant Deposit (FCD) Date
2016-01-15Usage metrics
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