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Alkenyl substituted bicyclic nucleoside analogues retain nanomolar potency against Varicella Zoster Virus
journal contributionposted on 2023-06-08, 21:54 authored by Christopher McGuigan, Olivier Bidet, Marco Derudas, Graciela Andrei, Robert Snoeck, Jan Balzarini
Novel alkenyl substituted aryl bicyclic furano pyrimidines have been prepared and evaluated in vitro against Varicella Zoster Virus (VZV). The para-substituted analogues retain the nanomolar potency we have reported for p-alkyl analogues, while the ortho- and meta-alkenyl systems lose 3–4 orders of potency.
JournalBioorganic and Medicinal Chemistry
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- Chemistry Publications
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