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Analysis of prevalence of HIV-1 drug resistance in primary infections in the United Kingdom

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posted on 2023-06-08, 10:28 authored by Kholoud Porter, Deenan Pillay, Patricia Cane, Gill Dean, Duncan Churchill, Guy Baily, Susan Drake, Martin Fisher
Objectives: To identify changes since 1994 in the prevalence of resistance to anti-HIV drugs in primary HIV-1 infections in the United Kingdom. Design: Retrospective and prospective assessment of viruses obtained from people recently infected with HIV. Setting: Multiple centres (patients enrolled in the UK register of seroconverters) and a single large HIV clinic (active case ascertainment). Participants: 69 patients infected with HIV between June 1994 and August 2000. Main outcome measures: Prevalence of key mutations associated with drug resistance in the reverse transcriptase and protease genes of HIV-1, by year of infection. Results: Between June 1994 and August 2000, 10 (14%) of 69 newly infected patients had one or more key HIV-1 mutations associated with drug resistance. The risk of being infected with drug resistant virus increased over time (adjusted relative risk per year 1.74 (95% confidence interval 0.93 to 3.27), P=0.06). The estimated prevalence of drug resistance in those infected in 2000 was 27% (12% to 48%). Conclusions: Transmission of drug resistant HIV-1 in the United Kingdom seems to be increasing. New approaches to encourage safer sexual behaviour in all sectors of the population are urgently needed. What is already known on this topic: The emergence of HIV drug resistance in patients receiving antiretroviral therapy is common. Transmission of virus variants resistant to anti-HIV drugs has been documented. What this paper adds: The prevalence of transmitted HIV drug resistance in the United Kingdom is increasing, exceeding 20% in 2000. New approaches to encourage safer sexual behaviour are urgently needed.


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