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Ancestral circuits for vertebrate color vision emerge at the first retinal synapse

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posted on 2023-06-10, 01:38 authored by Takeshi YoshimatsuTakeshi Yoshimatsu, Philipp Bartel, Cornelius Schröder, Filip JaniakFilip Janiak, François St-Pierre, Philipp Berens, Thomas BadenThomas Baden
For color vision, retinal circuits separate information about intensity and wavelength. In vertebrates that use the full complement of four “ancestral” cone types, the nature and implementation of this computation remain poorly understood. Here, we establish the complete circuit architecture of outer retinal circuits underlying color processing in larval zebrafish. We find that the synaptic outputs of red and green cones efficiently rotate the encoding of natural daylight in a principal components analysis–like manner to yield primary achromatic and spectrally opponent axes, respectively. Blue cones are tuned to capture most remaining variance when opposed to green cones, while UV cone present a UV achromatic axis for prey capture. We note that fruitflies use essentially the same strategy. Therefore, rotating color space into primary achromatic and chromatic axes at the eye’s first synapse may thus be a fundamental principle of color vision when using more than two spectrally well-separated photoreceptor types.

Funding

Anisotropic retinal circuits for processing of colour and space in nature; G2397; BBSRC-BIOTECHNOLOGY & BIOLOGICAL SCIENCES RESEARCH COUNCIL; BB/R014817/1

How to connect an eye to a brain; G3137; WELLCOME TRUST; WT Ref: 220277/

EMBO Young Investigator Programme; G2920; EMBO-EUROPEAN MOLECULAR BIOLOGY ORGANIZATION; Baden

Philip Leverhulme Prize - Biological Sciences; G2276; LEVERHULME TRUST; PLP-2017-005

Anisotropic retinal circuits for processing of colour and space in nature - Lister Institute Research Prize; G2503; LISTER INSTITUTE

NeuroVisEco - Zebrafish vision in its natural context: from natural scenes through retinal and central processing to behaviour; G1871; EUROPEAN UNION; 677687

History

Publication status

  • Published

File Version

  • Published version

Journal

Science Advances

ISSN

2375-2548

Publisher

American Association for the Advancement of Science

Issue

42

Volume

7

Page range

1-18

Event location

United States

Department affiliated with

  • Neuroscience Publications

Full text available

  • Yes

Peer reviewed?

  • Yes

Legacy Posted Date

2021-11-04

First Open Access (FOA) Date

2021-11-04

First Compliant Deposit (FCD) Date

2021-11-03

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