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Antihypertensives, angiotensin, glucose and Alzheimer’s disease
journal contribution
posted on 2023-06-08, 16:41 authored by Lucy Nelson, Naji TabetNaji Tabet, Cassie Richardson, Paul GardEvidence supporting a link between vascular disorders such as hypertension and Alzheimer’s disease (AD) is increasing. Population studies have suggested an association between hypertension and an increased risk of developing AD. A potential role for antihypertensive medications in the management of cognitive disorders has also been suggested, although findings are mixed. However, it is of interest that evidence is now leaning towards the possibility that some of these antihypertensive medications may improve cognition independent of their blood pressure lowering effects. Many of these drugs cross the blood–brain barrier and may influence neurotransmitters involved in cognition. Increasing knowledge of the actions of antihypertensives in the brain and the vascular system could lead to better treatment and/or prevention options for AD.
History
Publication status
- Published
File Version
- Published version
Journal
Expert Review of NeurotherapeuticsISSN
1473-7175Publisher
Expert ReviewsExternal DOI
Issue
5Volume
13Page range
477-482Department affiliated with
- Clinical and Experimental Medicine Publications
Full text available
- No
Peer reviewed?
- Yes