File(s) not publicly available
Application of the phosphoramidate ProTide approach to the antiviral drug ribavirin
journal contributionposted on 2023-06-08, 21:50 authored by Marco Derudas, Andrea Brancale, Lieve Naesens, Johan Neyts, Jan Balzarini, Christopher McGuigan
Ribavirin is a nucleoside analogue with broad antiviral activity. Here we report the synthesis and biological evaluation of novel ribavirin ProTides designed to deliver the bioactive ribavirin monophosphate into cells. Some of the compounds display activity similar to the parent nucleoside against a range of viruses. Enzymatic, cell lysate and preliminary modeling studies have been performed to investigate the lack of enhancement of potency by the ProTides, and these indicate a failure at the final, amino acid cleavage step in the ProTide activation process, leading to inefficient release of the nucleoside monophosphate.
JournalBioorganic and Medicinal Chemistry
Department affiliated with
- Chemistry Publications
Full text available