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Atrial fibrillation and the risk of cardiovascular disease and mortality in the Hypertension in the Very Elderly Trial
journal contribution
posted on 2023-06-09, 20:19 authored by Riitta L Antikainen, Ruth Peters, Nigel S Beckett, Chakravarthi RajkumarChakravarthi Rajkumar, Christopher J BulpittObjective: To assess the prognostic value of electrocardiographic atrial fibrillation in older hypertensive people in the randomized, placebo-controlled Hypertension in the Very Elderly Trial. Methods: Hypertension in the Very Elderly Trial randomized 3845 hypertensive people aged 80 years and over, 3273 with electrographic data on the presence or absence of atrial fibrillation at baseline and without established cardiovascular disease. Multivariate Cox proportional hazard models were used to estimate hazard ratios with 95% confidence intervals (CIs) for all-cause mortality, incident fatal and nonfatal major cardiovascular events, all-stroke and all-heart failure. The mean follow-up time was 2.1 years. Results: Baseline prevalence of atrial fibrillation was 5.8%. Compared with people without atrial fibrillation at baseline, after adjustments the presence of atrial fibrillation was associated with increased risk of mortality (hazard ratio?=?2.49, 95% CI?=?1.80–3.44, P ?
History
Publication status
- Published
File Version
- Published version
Journal
Journal of HypertensionISSN
0263-6352Publisher
Lippincott, Williams & WilkinsExternal DOI
Issue
5Volume
38Page range
839-844Department affiliated with
- BSMS Publications
Full text available
- No
Peer reviewed?
- Yes
Legacy Posted Date
2020-01-21First Compliant Deposit (FCD) Date
2020-01-20Usage metrics
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