University of Sussex
Browse

Behavioral psychological symptoms of dementia and functional connectivity changes: a network-based study

Download (1010.44 kB)
journal contribution
posted on 2023-06-09, 22:23 authored by Laura Serra, Michela Bruschini, Carlotta Di Domenico, Matteo Mancini, Giulia Bechi Gabrielli, Sabrina Bonarota, Carlo Caltagirone, Mara Cercignani, Camillo Marra, Marco Bozzali
Behavioral and psychological symptoms of dementia (BPSD) are commonly observed since the early stage of Alzheimer's disease (AD) associated with structural brain changes. It is conceivable that they may also relate to functional brain changes. This resting-state functional MRI (RS-fMRI) study investigated the alterations within functional brain networks of a cohort of AD patients at different clinical stages who presented with BPSD. One hundred one AD patients and 56 patients with amnestic mild cognitive impairment underwent a neuropsychological evaluation including the Neuropsychiatry Inventory-12 (NPI-12). All patients and 35 healthy controls (HS) underwent 3T-MRI. Factor analysis was used to extract the principal factors from NPI-12, while RS-fMRI data were processed using graph theory to investigate functional connectivity. Five factors were extracted from NPI-12. Sixty-two percent of patients showed BPSD and functional brain connectivity changes in various networks compared to those without BPSD and HS. These changes contributed to account for patients' BPSD. This work opens new perspectives in terms of nonpharmacological interventions that might be designed to modulate brain connectivity and improve patients' BPSD.

History

Publication status

  • Published

File Version

  • Accepted version

Journal

Neurobiology of Aging

ISSN

0197-4580

Publisher

Elsevier

Volume

94

Page range

196-206

Event location

United States

Department affiliated with

  • BSMS Neuroscience Publications

Full text available

  • Yes

Peer reviewed?

  • Yes

Legacy Posted Date

2020-12-11

First Open Access (FOA) Date

2021-09-30

First Compliant Deposit (FCD) Date

2020-12-15

Usage metrics

    University of Sussex (Publications)

    Categories

    No categories selected

    Exports

    RefWorks
    BibTeX
    Ref. manager
    Endnote
    DataCite
    NLM
    DC