Biophysical interactions between pancreatic cancer cells and pristine carbon nanotube substrates: potential application for pancreatic cancer tissue engineering
journal contribution
posted on 2023-06-09, 13:54authored byBrigitta Matt-Domjan, Alice KingAlice King, Stella Totti, Csaba Matta, George Dover, Patrica Martinez, Anvar Zakhidov, Roberto La Ragione, Hugo Macedo, Izabela Jurewicz, Alan DaltonAlan Dalton, Eirini Velliou
Novel synthetic biomaterials able to support direct tissue growth and retain cellular phenotypical properties are promising building blocks for the development of tissue engineering platforms for accurate and fast therapy screening for cancer. The aim of this study is to validate an aligned, pristine multi-walled carbon nanotube (CNT) platform for in vitro studies of pancreatic cancer as a systematic understanding of interactions between cells and these CNT substrates is lacking. Our results demonstrate that our CNT scaffolds—which are easily tuneable to form sheets/fibers—support growth, proliferation, and spatial organization of pancreatic cancer cells, indicating their great potential in cancer tissue engineering.
History
Publication status
Published
File Version
Published version
Journal
Journal of Biomedical Materials Research Part B: Applied Biomaterials