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Carbon dots (C-dots) from cow manure with impressive subcellular selectivity tuned by simple chemical modification
journal contribution
posted on 2023-06-08, 20:38 authored by Cintya Barbosa, José R. Corrêa, Gisele A Medeiros, Gabrielle Barreto, Kelly G Magalhães, Aline L de Oliveira, John SpencerJohn Spencer, Marcelo O Rodrigues, Brenno A D NetoImproved cellular selectivity toward nucleoli staining was achieved by simple chemical modification of carbon dots (C-dots) synthesized from waste carbon sources such as cow manure (or from glucose). The C-dots were characterized and functionalized (amine-passivated) with ethylenediamine affording amide bonds exhibiting bright green fluorescence. The new modified C-dots were successfully applied as selective live cell fluorescence imaging probes with impressive subcellular selectivity and selectively stain nucleoli in breast cancer cell lineages (MCF-7). The C-dots were also tested in four other cellular models showing the same cellular selection in live cell-imaging experiments.
History
Publication status
- Published
Journal
Chemistry - A European JournalISSN
0947-6539Publisher
John Wiley & SonsExternal DOI
Issue
13Volume
21Page range
5055 -5060Department affiliated with
- Chemistry Publications
Full text available
- No
Peer reviewed?
- Yes
Legacy Posted Date
2015-05-04Usage metrics
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