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Cardiovascular and hepatic toxicity of cocaine: potential beneficial effects of modulators of oxidative stress
journal contribution
posted on 2023-06-08, 23:14 authored by Manuela Graziani, Letizia Antonilli, Anna Rita Togna, Maria Caterina Grassi, Aldo Badiani, Luciano SasoOxidative stress (OS) is thought to play an important role in the pharmacological and toxic effects of various drugs of abuse. Herein we review the literature on the mechanisms responsible for the cardiovascular and hepatic toxicity of cocaine with special focus on OS-related mechanisms. We also review the preclinical and clinical literature concerning the putative therapeutic effects of OS modulators (such as N-acetylcysteine, superoxide dismutase mimetics, nitroxides and nitrones, NADPH oxidase inhibitors, xanthine oxidase inhibitors, and mitochondriotropic antioxidants) for the treatment of cocaine toxicity. We conclude that available OS modulators do not appear to have clinical efficacy.
History
Publication status
- Published
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- Published version
Journal
Oxidative Medicine and Cellular LongevitiyISSN
1942-0900Publisher
Hindawi Publishing CorporationExternal DOI
Volume
2016Department affiliated with
- Psychology Publications
Full text available
- Yes
Peer reviewed?
- Yes
Legacy Posted Date
2015-11-19First Open Access (FOA) Date
2016-01-04First Compliant Deposit (FCD) Date
2015-11-19Usage metrics
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