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Central and effector memory CD4 and CD8 T-cell responses to tumor-associated antigens
journal contributionposted on 2023-06-08, 22:36 authored by Stefano Caserta, Jessica Geraldine Borger, Rose Zamoyska
Harnessing T-cell responses to constrain tumor growth is a realistic treatment aspiration in tumor medicine, as many tumors express specific tumor associated antigens that are recognized by the adaptive immune system. CD8 T cells have direct cytolytic activity against tumor cells, and CD4 T cells mount a variety of responses that have important influences on tumor growth. We discuss how individual T-cell subsets contribute to antitumor responses and the goals and problems associated with generating and/or maintaining effective multifunctional T-cell responses to provide long-term protection against tumors.
JournalCritical Reviews in Immunology
Department affiliated with
- Clinical and Experimental Medicine Publications
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