journal.pone.0133532.pdf (3.67 MB)
Complexity of multi-dimensional spontaneous EEG decreases during propofol induced general anaesthesia
journal contribution
posted on 2023-06-08, 22:05 authored by Michael Schartner, Anil SethAnil Seth, Quentin Noirhomme, Melanie Boly, Marie-Aurelie Bruno, Steven Laureys, Adam BarrettAdam BarrettEmerging neural theories of consciousness suggest a correlation between a specific type of neural dynamical complexity and the level of consciousness: When awake and aware, causal interactions between brain regions are both integrated (all regions are to a certain extent connected) and differentiated (there is inhomogeneity and variety in the interactions). In support of this, recent work by Casali et al (2013) has shown that Lempel-Ziv complexity correlates strongly with conscious level, when computed on the EEG response to transcranial magnetic stimulation. Here we investigated complexity of spontaneous high-density EEG data during propofol-induced general anaesthesia. We consider three distinct measures: (i) Lempel-Ziv complexity, which is derived from how compressible the data are; (ii) amplitude coalition entropy, which measures the variability in the constitution of the set of active channels; and (iii) the novel synchrony coalition entropy (SCE), which measures the variability in the constitution of the set of synchronous channels. After some simulations on Kuramoto oscillator models which demonstrate that these measures capture distinct ‘flavours’ of complexity, we show that there is a robustly measurable decrease in the complexity of spontaneous EEG during general anaesthesia.
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- Published
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- Published version
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PLoS ONEISSN
1932-6203Publisher
Public Library of ScienceExternal DOI
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8Volume
10Page range
1-21Article number
e0133532Department affiliated with
- Informatics Publications
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- Yes
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- Yes
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2015-08-10First Open Access (FOA) Date
2015-08-10First Compliant Deposit (FCD) Date
2015-08-10Usage metrics
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