Contrasting transcriptional responses of a virulent and an attenuated strain of Mycobacterium tuberculosis infecting macrophages

Li, Alice H; Waddell, Simon; Hinds, Jason; Malloff, Chad A; Bains, Manjeet; Hancock, Robert E; Lam, Wan L; Butcher, Philip D; Stokes, Richard W

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Contrasting transcriptional responses of a virulent and an attenuated strain of Mycobacterium tuberculosis infecting macrophages

journal contribution

posted on 2023-06-07, 16:22 authored by Alice H Li, Simon WaddellSimon Waddell, Jason Hinds, Chad A Malloff, Manjeet Bains, Robert E Hancock, Wan L Lam, Philip D Butcher, Richard W Stokes

Along with the recent identification of single nucleotide polymorphisms in H37Ra when compared to H37Rv, our demonstration of differential expression of PhoP-regulated and ESX-1 region-related genes during macrophage infection further highlights the significance of these genes in the attenuation of H37Ra.

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Published

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Published version

Journal

PLoS ONE

ISSN

1932-6203

Publisher

Public Library of Science

External DOI

https://doi.org/10.1371/journal.pone.0011066

Issue

6

Volume

5

Article number

e11066

Department affiliated with

Global Health and Infection Publications

Full text available

Yes

Peer reviewed?

Yes

Legacy Posted Date

2012-07-17

First Open Access (FOA) Date

2016-03-22

First Compliant Deposit (FCD) Date

2016-11-17

Contrasting transcriptional responses of a virulent and an attenuated strain of Mycobacterium tuberculosis infecting macrophages

History

Publication status

File Version

Journal

ISSN

Publisher

External DOI

Issue

Volume

Article number

Department affiliated with

Full text available

Peer reviewed?

Legacy Posted Date

First Open Access (FOA) Date

First Compliant Deposit (FCD) Date

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