Contrasting transcriptional responses of a virulent and an attenuated strain of Mycobacterium tuberculosis infecting macrophages
journal contributionposted on 2023-06-07, 16:22 authored by Alice H Li, Simon WaddellSimon Waddell, Jason Hinds, Chad A Malloff, Manjeet Bains, Robert E Hancock, Wan L Lam, Philip D Butcher, Richard W Stokes
Along with the recent identification of single nucleotide polymorphisms in H37Ra when compared to H37Rv, our demonstration of differential expression of PhoP-regulated and ESX-1 region-related genes during macrophage infection further highlights the significance of these genes in the attenuation of H37Ra.
- Published version
PublisherPublic Library of Science
Department affiliated with
- Global Health and Infection Publications
Full text available