File(s) under permanent embargo
Counterphase modulation flicker photometry: phenotypic and genotypic associations.
journal contribution
posted on 2023-06-08, 19:47 authored by A J Lawrance-Owen, Jenny BostenJenny Bosten, R E Hogg, G Bargary, P T Goodbourn, J D MollonThe OSCAR test, a clinical device that uses counterphase flicker photometry, is believed to be sensitive to the relative numbers of long-wavelength and middle-wavelength cones in the retina, as well as to individual variations in the spectral positions of the photopigments. As part of a population study of individual variations in perception, we obtained OSCAR settings from 1058 participants. We report the distribution characteristics for this cohort. A randomly selected subset of participants was tested twice at an interval of at least one week: the test-retest reliability (Spearman's rho) was 0.80. In a whole-genome association analysis we found a provisional association with a single nucleotide polymorphism (rs16844995). This marker is close to the gene RXRG, which encodes a nuclear receptor, retinoid X receptor ?. This nuclear receptor is already known to have a role in the differentiation of cones during the development of the eye, and we suggest that polymorphisms in or close to RXRG influence the relative probability with which long-wave and middle-wave opsin genes are expressed in human cones.
History
Publication status
- Published
File Version
- Published version
Journal
Journal of the Optical Society of America AISSN
1084-7529Publisher
Optical Society of AmericaExternal DOI
Issue
4Volume
31Article number
A226-A231Department affiliated with
- Psychology Publications
Full text available
- No
Peer reviewed?
- Yes
Legacy Posted Date
2015-01-28First Compliant Deposit (FCD) Date
2015-01-28Usage metrics
Categories
No categories selectedKeywords
Licence
Exports
RefWorks
BibTeX
Ref. manager
Endnote
DataCite
NLM
DC