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Covid-19 effects on ARTErial StIffness and vascular AgeiNg: CARTESIAN study rationale and protocol
journal contribution
posted on 2023-06-10, 04:37 authored by Rosa M Bruno, Bart Spronck, Bernhard Hametner, Alun Hughes, Patrick Lacolley, Christopher C Mayer, Maria L Muiesan, Chakravarthi RajkumarChakravarthi Rajkumar, Dimitrios Terentes-Printzios, Thomas Weber, Tine W Hansen, Pierre Boutouyrie, ARTERY SocietyIn December 2019, an outbreak of pneumonia caused by a novel Coronavirus (COVID-19) spread rapidly worldwide. Although the clinical manifestations of COVID-19 are dominated by respiratory symptoms, the cardiovascular system is extensively affected at multiple levels. Due to the unprecedented consequences of the COVID-19 pandemic, the ARTERY society decided to launch the Covid-19 effects on ARTErial StIffness and vascular AgeiNg (CARTESIAN) study — the first international multicentre study into the effects of COVID-19 on non-invasive biomarkers of vascular ageing. The main study objective is to evaluate the presence of Early Vascular Ageing (EVA) 6 and 12 months after COVID-19 infection. Secondary objectives are to study the effect of COVID-19 disease severity on EVA, to investigate the role of psychosocial factors in COVID-19 induced EVA, and to investigate the potential modifying effect of comorbidities and chronic treatments. In the CARTESIAN study, a broad array of cardiovascular measurements, including carotid-femoral pulse wave velocity, central blood pressure, carotid ultrasound, brachial flow-mediated dilatation, will be performed. To date, 43 centres from 21 countries have agreed to participate, with an expected study population of >2500 individuals. To our knowledge, CARTESIAN will be the first study to provide insight into the relationship between COVID-19, its severity, and early vascular ageing in a large cohort, potentially enabling future care and diagnostics to be more focused on the most vulnerable.
History
Publication status
- Published
File Version
- Published version
Journal
Artery ResearchISSN
1872-9312Publisher
Springer Science and Business Media LLCExternal DOI
Issue
2Volume
27Page range
59-68Event location
NetherlandsDepartment affiliated with
- Clinical and Experimental Medicine Publications
Full text available
- Yes
Peer reviewed?
- Yes
Legacy Posted Date
2022-09-08First Open Access (FOA) Date
2022-09-08First Compliant Deposit (FCD) Date
2022-09-08Usage metrics
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