University of Sussex
Browse

File(s) under permanent embargo

Cytoplasmic dynein heavy chain: the servant of many masters

journal contribution
posted on 2023-06-08, 16:19 authored by Giampietro Schiavo, Linda Greensmith, Majid HafezparastMajid Hafezparast, Elizabeth M C Fisher
Cytoplasmic dynein is the main retrograde motor in all eukaryotic cells. This complex comprises different subunits assembled on a cytoplasmic dynein heavy chain 1 (DYNC1H1) dimer. Cytoplasmic dynein is particularly important for neurons because it carries essential signals and organelles from distal sites to the cell body. In the past decade, several mouse models have helped to dissect the numerous functions of DYNC1H1. Additionally, several DYNC1H1 mutations have recently been found in human patients that give rise to a broad spectrum of developmental and midlife-onset disorders. Here, we discuss the effects of mutations of mouse and human DYNC1H1 and how these studies are giving us new insight into the many critical roles DYNC1H1 plays in the nervous system.

History

Publication status

  • Published

File Version

  • Published version

Journal

Trends in Neurosciences

ISSN

1878-108X

Publisher

Elsevier

Issue

11

Volume

36

Page range

641-651

Department affiliated with

  • Neuroscience Publications

Full text available

  • No

Peer reviewed?

  • Yes

Legacy Posted Date

2013-11-14

First Compliant Deposit (FCD) Date

2013-11-14

Usage metrics

    University of Sussex (Publications)

    Categories

    No categories selected

    Exports

    RefWorks
    BibTeX
    Ref. manager
    Endnote
    DataCite
    NLM
    DC