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DNA damage and transcription stress

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journal contribution
posted on 2024-02-09, 09:59 authored by Larissa MilanoLarissa Milano, Amit GautamAmit Gautam, Keith CaldecottKeith Caldecott
Genome damage and transcription are intimately linked. Tens to hundreds of thousands of DNA lesions arise in each cell each day, many of which can directly or indirectly impede transcription. Conversely, the process of gene expression is itself a source of endogenous DNA lesions as a result of the susceptibility of single-stranded DNA to damage, conflicts with the DNA replication machinery, and engagement by cells of topoisomerases and base excision repair enzymes to regulate the initiation and progression of gene transcription. Although such processes are tightly regulated and normally accurate, on occasion, they can become abortive and leave behind DNA breaks that can drive genome rearrangements, instability, or cell death.

Funding

Mechanisms of DNA Single-Strand Break-Induced Genetic Disease and Opportunities for Therapeutic Intervention : MRC-MEDICAL RESEARCH COUNCIL | MR/W024128/1

History

Publication status

  • Published

File Version

  • Published version

Journal

Molecular Cell

ISSN

1097-2765

Publisher

Elsevier BV

Issue

1

Volume

84

Page range

70-79

Department affiliated with

  • Sussex Centre for Genome Damage Stability Publications

Institution

University of Sussex

Full text available

  • Yes

Peer reviewed?

  • Yes