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DNA repair, genome stability and cancer: a historical perspective
journal contribution
posted on 2023-06-09, 00:01 authored by Penny A Jeggo, Laurence PearlLaurence Pearl, Antony M CarrThe multistep process of cancer progresses over many years. The prevention of mutations by DNA repair pathways led to an early appreciation of a role for repair in cancer avoidance. However, the broader role of the DNA damage response (DDR) emerged more slowly. In this Timeline article, we reflect on how our understanding of the steps leading to cancer developed, focusing on the role of the DDR. We also consider how our current knowledge can be exploited for cancer therapy.
History
Publication status
- Published
Journal
Nature Reviews CancerISSN
1474-1768Publisher
Nature Publishing GroupExternal DOI
Issue
1Volume
16Page range
35-42Department affiliated with
- Sussex Centre for Genome Damage Stability Publications
Full text available
- No
Peer reviewed?
- Yes
Legacy Posted Date
2016-01-15Usage metrics
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