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Depression and anxiety both associate with serum level of hs-CRP: a gender- stratified analysis in a population-based study

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posted on 2023-06-09, 06:10 authored by Maryam Tayefi, Mojtaba Shafiee, Seyyed Mohammad Reza Kazemi-Bajestani, Habibolah Esmaeili, Susan Darroudi, Samaneh Khakpouri, Maryam Mohammadi, Zahra Ghaneifar, Mahmoud Reza Azarpajouh, Mohsen Moohebati, Alireza Heidari-Bakavoli, Mohammad Reza Parizadeh, Mohsen Nematy, Mohammad Safarian, Mahmoud Ebrahimi, Gordon FernsGordon Ferns, Naghmeh Mokhber, Majid Ghayour-Mobarhan
Background: Depression and anxiety are two important mood disorders that are frequently associated with chronic diseases such as cardiovascular diseases (CVDs). Hyper-inflammation is related to both CVDs and psychological conditions such as depression and anxiety. Therefore, inflammation may partially explain the relationship between depression and cardiovascular disease. Objective: The objective of this study was to perform a gender-stratified examination of the association between symptoms of depression/anxiety disorders and serum hs-CRP and inflammation linked conditions in a large Iranian population. Methods: Symptoms of depression and anxiety disorders and serum hs-CRP levels were measured in 9759 participants (40% males and 60% females) aged 35–65 years, enrolled in a population-based cohort (MASHAD) study in north-eastern Iran. Symptoms of depression and anxiety were evaluated with Beck Depression and Anxiety Inventories. According to the scores of depression and anxiety, individuals were categorized into four groups of no or minimal, low, moderate and severe categories. Results: The median serum hs-CRP concentration increased with increasing severity of depression and anxiety disorders. Male participants with severe depression had significantly higher levels of hs-CRP (p < 0.001); however, this relationship was less marked among women (p = 0.04). Subjects with severe anxiety also had significantly higher levels of hs-CRP (p < 0.001). Moreover, women with severe depression and anxiety had higher BMI. There was also a positive association between current smoking habit and depression/anxiety disorders. Conclusion: Depression and anxiety disorders are associated with elevated levels of hs-CRP, particularly among men. Also, there is a significant positive association between depression/anxiety disorders and inflammation linked conditions such as smoking and obesity; however, in the case of obesity this association is only present in women.

History

Publication status

  • Published

File Version

  • Accepted version

Journal

Psychoneuroendocrinology

ISSN

0306-4530

Publisher

Elsevier

Volume

81

Page range

63-69

Department affiliated with

  • Division of Medical Education Publications

Full text available

  • Yes

Peer reviewed?

  • Yes

Legacy Posted Date

2017-05-08

First Open Access (FOA) Date

2018-04-03

First Compliant Deposit (FCD) Date

2017-05-08

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