journal.pmed.1001538.pdf (1.37 MB)
Detection of tuberculosis in HIV-infected and - uninfected African adults using whole blood RNA expression signatures: a case-control study
journal contribution
posted on 2023-06-08, 17:42 authored by Adithya Cattamanchi, Myrsini Kaforou, Victoria J Wright, Tolu Oni, Neil French, Suzanne T Anderson, Nonzwakazi Bangani, Claire M Banwell, Andrew J Brent, Amelia C Crampin, Hazel M Dockrell, Brian Eley, Robert S Heyderman, Martin L Hibberd, Florian KernFlorian Kern, Paul R Langford, Ling Ling, Marc Mendelson, Tom H Ottenhoff, Femia Zgambo, Robert J Wilkinson, Lachlan J Coin, Michael LevinA major impediment to tuberculosis control in Africa is the difficulty in diagnosing active tuberculosis (TB), particularly in the context of HIV infection. We hypothesized that a unique host blood RNA transcriptional signature would distinguish TB from other diseases (OD) in HIV-infected and -uninfected patients, and that this could be the basis of a simple diagnostic test.
History
Publication status
- Published
File Version
- Published version
Journal
PLoS MedicineISSN
1549-1676Publisher
Public Library of ScienceExternal DOI
Issue
10Volume
10Article number
e1001538Department affiliated with
- Clinical and Experimental Medicine Publications
Full text available
- Yes
Peer reviewed?
- Yes
Legacy Posted Date
2014-07-02First Open Access (FOA) Date
2014-07-02First Compliant Deposit (FCD) Date
2014-07-02Usage metrics
Categories
No categories selectedKeywords
Licence
Exports
RefWorks
BibTeX
Ref. manager
Endnote
DataCite
NLM
DC