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Determining the functional role of TRPC channels in primary cells
journal contribution
posted on 2023-06-08, 19:47 authored by Su Li, Martin Gosling, Chris PollAlthough the TRPC members of the mammalian transient receptor potential TRP cation channel family were the first to be described in 1995, the depth of knowledge of TRPC channels has fallen behind that of their counterparts in the TRPV and TRPM subfamilies in the intervening years. The complexities and controversies of TRPC channel composition and regulation have hindered their progress as therapeutic targets in the drug discovery environment to date, however embracing these challenges as opportunities may bring TRPC channels to the forefront of the discovery of novel therapies for many diseases. These challenges and opportunities of exploring TRPC channels as therapeutic targets are highlighted and discussed in this review with respect to respiratory diseases. © Springer-Verlag 2005.
History
Publication status
- Published
Journal
Pflugers Archiv European Journal of PhysiologyISSN
0031-6768Publisher
Springer-VerlagExternal DOI
Issue
1Volume
451Page range
43-52Department affiliated with
- Chemistry Publications
Full text available
- No
Peer reviewed?
- Yes