File(s) not publicly available
Diffraction to study protein and peptide assemblies
journal contributionposted on 2023-06-08, 06:24 authored by O Sumner Makin, Pawel Sikorski, Louise SerpellLouise Serpell
Proteins and peptides are able to self-assemble in vivo and in vitro. In vitro, this ability can be exploited to make bionanomaterials with many potential uses. Peptides are capable of forming a wide range of structures including fibres, tubules and scaffolds. In vivo, proteins assemble to form cellular fibrous proteins, as well as being involved in protein misfolding in disease. Recent advances using X-ray diffraction have highlighted the internal structure of self-assembled proteins and peptides, showing packing of side chain residues and have enabled a deeper understanding of mechanisms of assembly.
JournalCurrent Opinion in Chemical Biology
Department affiliated with
- Biochemistry Publications
Full text available