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Diseases, disorders, and comorbidities of interoception
journal contribution
posted on 2023-06-10, 03:53 authored by Bruno Bonaz, Richard D Lane, Michael L Oshinsky, Paul J Kenny, Rajita Sinha, Emeran A Mayer, Hugo CritchleyHugo CritchleyInteroception, the sense of the body's internal physiological state, underpins homeostatic reflexes, motivational states, and sensations contributing to emotional experiences. The continuous nature of interoceptive processing, coupled to behavior, is implicated in the neurobiological construction of the sense of self. Aberrant integration and control of interoceptive signals, originating in the brain and/or the periphery, can perturb the whole system. Interoceptive abnormalities are implicated in the pathophysiology of psychiatric disorders and in the symptomatic expression of developmental, neurodegenerative, and neurological disorders. Moreover, interoceptive mechanisms appear central to somatic disorders of brain–body interactions, including functional digestive disorders, chronic pain, and comorbid conditions. The present article provides an overview of disorders of interoception and suggests future directions for better understanding, diagnosis, and management of these disorders.
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Publication status
- Published
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- Published version
Journal
Trends in NeurosciencesISSN
0166-2236Publisher
Elsevier BVExternal DOI
Issue
1Volume
44Page range
39-51Event location
EnglandDepartment affiliated with
- BSMS Neuroscience Publications
Full text available
- No
Peer reviewed?
- Yes
Legacy Posted Date
2022-06-15First Compliant Deposit (FCD) Date
2022-06-13Usage metrics
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