fmc-2017-0062 lineham morley spencer.pdf (1.78 MB)
Download fileDual abrogation of Mnk and mTOR; a novel therapeutic approach for the treatment of aggressive cancers
journal contribution
posted on 2023-06-09, 06:29 authored by Ella Lineham, John SpencerJohn Spencer, Simon MorleyTargeting the translational machinery has emerged as a promising therapeutic option for cancer treatment. Cancer cells require elevated protein synthesis for cell growth and exhibit augmented activity to meet the increased metabolic demand. Eukaryotic translation initiation factor 4E (eIF4E) is necessary for mRNA translation, its availability and phosphorylation are regulated by the PI3K/AKT/mTOR and Mnk1/2 pathways, respectively. The phosphorylated form of eIF4E drives the expression of oncogenic proteins including those involved in metastasis. This article will review the role of eIF4E in cancer, its regulation, and discuss the benefit of dual-inhibition of upstream pathways. The discernible interplay between the Mnk1/2 and mTOR signaling pathways provides a novel therapeutic opportunity to target aggressive migratory cancers through the development of hybrid molecules.
Funding
The re-modelling of mRNPs and the regulation of localised mRNA translation during mammalian cell attachment and spreading; G1479; BBSRC; BB/L018209/1
History
Publication status
- Published
File Version
- Published version
Journal
Future Medicinal ChemistryISSN
1756-8919Publisher
Future ScienceExternal DOI
Issue
13Volume
9Department affiliated with
- Biochemistry Publications
Full text available
- Yes
Peer reviewed?
- Yes