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Ethiopian medicinal plants used for their anti-inflammatory, wound healing or anti-infective activities: protocol for systematic literature review and meta-analysis
journal contribution
posted on 2023-06-09, 21:36 authored by Dereje Nigussie, Belete Adefris Legesse, Gail DaveyGail Davey, Abebaw Fekadu, Eyasu MakonnenObjectives Medicinal plants are used globally as alternative medicines in the management of a range of disease conditions and are widely accepted across differing societies. Ethiopia hosts a large number of plant species (>7000 higher plant species), of which around 12% are thought to be endemic, making it a rich source of plant extracts potentially useful for human health. The aim of this review is to evaluate Ethiopian medicinal plants for their anti-inflammatory, wound healing, antifungal or antibacterial activities. Methods and analysis The guidance of the Preferred Reporting Items for Systematic Review and Meta-analysis Protocols (PRISMA-P) statement will be used. This review will consider all controlled studies of anti-inflammatory and wound healing properties (both in vivo and in vitro) and in vitro anti-infective properties of medicinal plants found in Ethiopia. Data sources will be EMBASE, PubMed/Medline, Scopus and Google Scholar. Guidance documents on good in vitro methods and checklists for reporting in vitro studies will be used for quality assessment of in vitro studies. The risk of bias tool for animal intervention studies (the SYRCLE RoB tool) will be used to assess the validity of studies. The main outcomes will be percent inhibition of inflammation, time of epithelisation and tissue tensile strength in wounds and microbial growth inhibition. Ethics and dissemination The findings of this systematic review will be disseminated by publishing in a peer-reviewed journal and via conference presentations. Ethical clearance was obtained from the Brighton and Sussex Medical School, Research Governance & Ethics Committee (RGEC) and Addis Ababa University, College of Health Science, Institutional Review Board.
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- Published
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- Published version
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BMJ Open ScienceISSN
2398-8703Publisher
BMJ Publishing GroupExternal DOI
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4Page range
1-8Article number
a100064Department affiliated with
- Global Health and Infection Publications
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- Yes
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- Yes
Legacy Posted Date
2020-09-16First Open Access (FOA) Date
2020-09-16First Compliant Deposit (FCD) Date
2020-09-16Usage metrics
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