Evaluating the Effects of SARS-CoV-2 Spike Mutation D614G on Transmissibility and Pathogenicity

Volz, E; Hill, V; McCrone, JT; Price, A; Jorgensen, D; O'Toole, Á; Southgate, J; Johnson, R; Jackson, B; Nascimento, FF; Rey, SM; Nicholls, SM; Colquhoun, RM; da Silva Filipe, A; Shepherd, J; Pascall, DJ; Shah, R; Jesudason, N; Li, K; Jarrett, R; Pacchiarini, N; Bull, M; Geidelberg, L; Siveroni, I; Koshy, C; Wise, E; Cortes, N; Lynch, J; Kidd, S; Mori, M; Fairley, DJ; Curran, T; McKenna, JP; Adams, H; Fraser, C; Golubchik, T; Bonsall, D; Moore, C; Caddy, SL; Khokhar, FA; Wantoch, M; Reynolds, N; Warne, B; Maksimovic, J; Spellman, K; McCluggage, K; John, M; Beer, R; Afifi, S; Morgan, S; Marchbank, A; Kitchen, C; Gulliver, H; Merrick, I; Guest, M; Munn, R; Workman, T; Connor, TR; Fuller, W; Bresner, C; Snell, LB; Charalampous, T; Nebbia, G; Batra, R; Edgeworth, J; Robson, SC; Beckett, A; Loveson, KF; Aanensen, DM; Underwood, AP; Yeats, CA; Abudahab, K; Taylor, BEW; Menegazzo, M; Clark, G; Smith, W; Khakh, M; Fleming, VM; Lister, MM; Howson-Wells, HC; Berry, L; Boswell, T; Joseph, A; Willingham, I; Bird, P; Helmer, T; Fallon, K; Holmes, C; Tang, J; Raviprakash, V; Campbell, S; Sheriff, N; Loose, MW; Holmes, N; Carlile, M; Wright, V; Sang, F; Debebe, J; Coll, F

Volz 2 2021.pdf (3.74 MB)

Evaluating the Effects of SARS-CoV-2 Spike Mutation D614G on Transmissibility and Pathogenicity

journal contribution

posted on 2023-08-02, 09:16 authored by E Volz, V Hill, JT McCrone, A Price, D Jorgensen, Á O'Toole, J Southgate, R Johnson, B Jackson, FF Nascimento, SM Rey, SM Nicholls, RM Colquhoun, A da Silva Filipe, J Shepherd, DJ Pascall, R Shah, N Jesudason, K Li, R Jarrett, N Pacchiarini, M Bull, L Geidelberg, I Siveroni, C Koshy, E Wise, N Cortes, J Lynch, S Kidd, M Mori, DJ Fairley, T Curran, JP McKenna, H Adams, C Fraser, T Golubchik, D Bonsall, C Moore, SL Caddy, FA Khokhar, M Wantoch, N Reynolds, B Warne, J Maksimovic, K Spellman, K McCluggage, M John, R Beer, S Afifi, S Morgan, A Marchbank, C Kitchen, H Gulliver, I Merrick, M Guest, R Munn, T Workman, TR Connor, W Fuller, C Bresner, LB Snell, T Charalampous, G Nebbia, R Batra, J Edgeworth, SC Robson, A Beckett, KF Loveson, DM Aanensen, AP Underwood, CA Yeats, K Abudahab, BEW Taylor, M Menegazzo, G Clark, W Smith, M Khakh, VM Fleming, MM Lister, HC Howson-Wells, L Berry, T Boswell, A Joseph, I Willingham, P Bird, T Helmer, K Fallon, C Holmes, J Tang, V Raviprakash, S Campbell, N Sheriff, MW Loose, N Holmes, M Carlile, V Wright, F Sang, J Debebe, F Coll

Analysis of the spread and frequency of SARS-CoV-2 D614G in the United Kingdom suggests a selective advantage for this strain that is associated with higher viral loads in younger patients but not higher COVID-19 clinical severity or mortality.

History

Publication status

Published

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Published version

Journal

Cell

ISSN

0092-8674

Publisher

Elsevier BV

Publisher URL

http://dx.doi.org/10.1016/j.cell.2020.11.020

External DOI

https://doi.org/10.1016/j.cell.2020.11.020

Issue

1

Volume

184

Page range

64-75.e11

Department affiliated with

BSMS Publications
Global Health and Infection Publications

Full text available

Yes

Peer reviewed?

Yes

Evaluating the Effects of SARS-CoV-2 Spike Mutation D614G on Transmissibility and Pathogenicity

History

Publication status

File Version

Journal

ISSN

Publisher

Publisher URL

External DOI

Issue

Volume

Page range

Department affiliated with

Full text available

Peer reviewed?

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