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Evaluation of N-(phenylmethyl)-4-[5-(phenylmethyl)-4,5,6,7-tetrahydro-1H-imidazo[4,5-c]pyridin-4-yl]benzamide inhibitors of Mycobacterium tuberculosis growth
journal contributionposted on 2023-06-08, 19:30 authored by Michael D Wall, Michael Oshin, Gavin A C Chung, Tony Parkhouse, Andrea Gore, Esperanza Herreros, Brian Cox, Ken Duncan, Brian Evans, Martin Everett, Alfonso Mendoza
The biological evaluation of imidazopiperidines as FAS II inhibitors of Mycobacterium tuberculosis growth has been carried out with a view to assessment of potential as lead compounds for the development of a new TB drug. A summary of the hit evaluation and current challenges is described herein.
JournalBioorganic and Medicinal Chemistry Letters
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