Evaluation of N-(phenylmethyl)-4-[5-(phenylmethyl)-4,5,6,7-tetrahydro-1H-imidazo[4,5-c]pyridin-4-yl]benzamide inhibitors of Mycobacterium tuberculosis growth

Wall, Michael D; Oshin, Michael; Chung, Gavin A C; Parkhouse, Tony; Gore, Andrea; Herreros, Esperanza; Cox, Brian; Duncan, Ken; Evans, Brian; Everett, Martin; Mendoza, Alfonso

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Evaluation of N-(phenylmethyl)-4-[5-(phenylmethyl)-4,5,6,7-tetrahydro-1H-imidazo[4,5-c]pyridin-4-yl]benzamide inhibitors of Mycobacterium tuberculosis growth

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posted on 2023-06-08, 19:30 authored by Michael D Wall, Michael Oshin, Gavin A C Chung, Tony Parkhouse, Andrea Gore, Esperanza Herreros, Brian Cox, Ken Duncan, Brian Evans, Martin Everett, Alfonso Mendoza

The biological evaluation of imidazopiperidines as FAS II inhibitors of Mycobacterium tuberculosis growth has been carried out with a view to assessment of potential as lead compounds for the development of a new TB drug. A summary of the hit evaluation and current challenges is described herein.

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Publication status

Published

Journal

Bioorganic and Medicinal Chemistry Letters

ISSN

0960-894X

Publisher

Elsevier

External DOI

https://doi.org/10.1016/j.bmcl.2007.02.078

Issue

10

Volume

17

Page range

2740-2744

Department affiliated with

Chemistry Publications

Full text available

No

Peer reviewed?

Yes

Legacy Posted Date

2015-01-13

File(s) not publicly available

Evaluation of N-(phenylmethyl)-4-[5-(phenylmethyl)-4,5,6,7-tetrahydro-1H-imidazo[4,5-c]pyridin-4-yl]benzamide inhibitors of Mycobacterium tuberculosis growth

History

Publication status

Journal

ISSN

Publisher

External DOI

Issue

Volume

Page range

Department affiliated with

Full text available

Peer reviewed?

Legacy Posted Date

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