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Extracellular vesicles as mediators of therapy resistance in breast cancer microenvironment

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posted on 2023-06-10, 02:23 authored by Mark SamuelsMark Samuels, Chiara Cilibrasi, Panagiotis Papanastasopoulos, Georgios GiamasGeorgios Giamas
Resistance to various therapies, including novel immunotherapies, poses a major challenge in the management of breast cancer and is the leading cause of treatment failure. Bidirectional communication between breast cancer cells and the tumour microenvironment is now known to be an important contributor to therapy resistance. Several studies have demonstrated that crosstalk with the tumour microenvironment through extracellular vesicles is an important mechanism employed by cancer cells that leads to drug resistance via changes in protein, lipid and nucleic acid cargoes. Moreover, the cargo content enables extracellular vesicles to be used as effective biomarkers for predicting response to treatments and as potential therapeutic targets. This review summarises the literature to date regarding the role of extracellular vesicles in promoting therapy resistance in breast cancer through communication with the tumour microenvironment.

History

Publication status

  • Published

File Version

  • Published version

Journal

Biomolecules

ISSN

2218-273X

Publisher

MDPI

Issue

1

Volume

12

Page range

1-40

Department affiliated with

  • Biochemistry Publications

Full text available

  • Yes

Peer reviewed?

  • Yes

Legacy Posted Date

2022-01-20

First Open Access (FOA) Date

2022-01-20

First Compliant Deposit (FCD) Date

2022-01-20

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