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Extracellular vesicles swarm the cancer microenvironment: from tumor–stroma communication to drug intervention

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posted on 2023-06-09, 02:39 authored by F Wendler, R Favicchio, T Simon, C Alifrangis, J Stebbing, Georgios GiamasGeorgios Giamas
Intercellular communication sets the pace for transformed cells to survive and to thrive. Extracellular vesicles (EVs), such as exosomes, microvesicles and large oncosomes, are involved in this process shuttling reciprocal signals and other molecules between transformed and stromal cells, including fibroblasts, endothelial and immune cells. As a result, these cells are adapted or recruited to a constantly evolving cancer microenvironment. Moreover, EVs take part in the response to anticancer therapeutics not least by promoting drug resistance throughout the targeted tumor. Finally, circulating EVs can also transport important molecules to remote destinations in order to prime metastatic niches in an otherwise healthy tissue. Although the understanding of EV biology remains a major challenge in the field, their characteristics create new opportunities for advances in cancer diagnostics and therapeutics.

History

Publication status

  • Published

File Version

  • Accepted version

Journal

Oncogene

ISSN

0950-9232

Publisher

Nature Publishing Group

Issue

7

Volume

36

Page range

877-884

Department affiliated with

  • Biochemistry Publications

Full text available

  • Yes

Peer reviewed?

  • Yes

Legacy Posted Date

2016-08-26

First Open Access (FOA) Date

2017-02-23

First Compliant Deposit (FCD) Date

2016-08-26

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