CERI-D-19-08689R1 Scaffold DLP.pdf (2.11 MB)
Fabrication and properties of zirconia/hydroxyapatite composite scaffold based on digital light processing
journal contribution
posted on 2023-06-09, 19:11 authored by Ying Cao, Tianshu Shi, Chen Jiao, Huixin Liang, Ruoyu Chen, Zongjun Tian, Anchao Zou, Youwen Yang, Zhen Wei, Chang WangChang Wang, Lida ShenZirconia and hydroxyapatite(HA) are two typical implant materials, which have the advantages of excellent mechanical strength and good biological activity respectively. It was found that composite material had good biocompatibility and mechanical strength compared to the single material. In this paper, the porous scaffolds of ZrO2/HA composite were formed by digital light processing (DLP) technology and their performance were evaluated. Cell experiments showed that the addition of HA had a positive effect on cell proliferation and differentiation. Mechanical tests showed that the composite scaffold with 10?wt% HA had the best compressive capacity due to the pinning and bridging effect of a small amount of HA grains. When scaffolds were immersed in the simulated body fluid (SBF), the compressive strengths of the composite scaffolds decreased within the first 14 days and gradually increased after 14 days. The reason for this phenomenon was the degradation of calcium phosphate components and the deposition of apatite. By the 28th day, the compressive strengths of all the composite scaffolds increased to over 20?MPa, close to that of the zirconia scaffolds during the same period (25?MPa). The compressive strengths of all scaffolds met the requirement of cancellous bone during the entire soaking period, and the composite scaffolds have potential application value in bone repair.
History
Publication status
- Published
File Version
- Accepted version
Journal
Ceramics InternationalISSN
02728842Publisher
ElsevierExternal DOI
Department affiliated with
- Engineering and Design Publications
Research groups affiliated with
- Dynamics, Control and Vehicle Research Group Publications
Full text available
- Yes
Peer reviewed?
- Yes
Legacy Posted Date
2019-10-01First Open Access (FOA) Date
2020-09-23First Compliant Deposit (FCD) Date
2019-09-27Usage metrics
Categories
No categories selectedKeywords
Licence
Exports
RefWorks
BibTeX
Ref. manager
Endnote
DataCite
NLM
DC