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Frailty in people living with HIV: an update

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posted on 2023-06-10, 04:33 authored by Howell T Jones, Thomas LevettThomas Levett, Tristan J Barber
Purpose of review: The HIV population is ageing with rising rates of frailty though strategies of how best to manage it remain ill-defined. It also remains unclear what the prevalence of frailty is within this cohort, how best to diagnose it and what factors are associated. RECENT FINDINGS: The prevalence of frailty remains unclear because of heterogenous results. Routine screening in those 50+ is recommended and whilst the Fried Frailty Phenotype is currently preferred the Clinical Frailty Scale could be considered. No biomarkers are currently recommended. Looking at associated factors, HIV neurocognitive impairment and long-term alcohol usage has been shown to be associated with developing frailty whilst those who are frail have been shown to be less active and more likely to fall. NAFLD with fibrosis has been shown to be an indicator of metabolic age and the Pooled Cohort Equations has been shown to be more effective in diagnosing cardiovascular risk in frail people living with HIV. SUMMARY: Whilst the prevalence of frailty differs between countries, with the addition of prefrailty, this represents a large proportion of people living with HIV. Services must ensure strategies are in place to support those living with HIV and frailty. Further longitudinal studies are required.


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  • Published

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  • Accepted version


Current Opinion in Infectious Diseases




Lippincott, Williams & Wilkins





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United States

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  • Clinical and Experimental Medicine Publications


This is a pre-copyedited, author-produced version of an article accepted for publication in Current Opinion in Infectious Diseases. The published version of record Frailty in people living with HIV: an update is available online at:

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