Stephens_et_al-2016-Genes,_Brain_and_Behavior.pdf (2.25 MB)
GABAA receptor subtype involvement in addictive behaviour
journal contribution
posted on 2023-06-09, 02:41 authored by D N Stephens, Sarah KingSarah King, J J Lambert, D Belelli, Dora DukaGABAA receptors form the major class of inhibitory neurotransmitter receptors in the mammalian brain. This review sets out to summarise the evidence that variations in genes encoding GABAA receptor isoforms are associated with aspects of addictive behaviour in humans, while animal models of addictive behaviour also implicate certain subtypes of GABAA receptor. In addition to outlining the evidence for the involvement of specific subtypes in addiction, we summarise the particular contributions of these isoforms in control over the functioning of brain circuits, especially the mesolimbic system, and make a first attempt to bring together evidence from several fields to understanding potential involvement of GABAA Receptor Subtypes in addictive behaviour. While the weight of the published literature is on alcohol dependency, the underlying principles outlined are relevant across a number of different aspects of addictive behaviour.
History
Publication status
- Published
File Version
- Accepted version
Journal
Genes, Brain and BehaviorISSN
1601-1848Publisher
WileyExternal DOI
Issue
1Volume
16Page range
149-184Department affiliated with
- Psychology Publications
Full text available
- Yes
Peer reviewed?
- Yes