File(s) not publicly available
Galactose-phosphonates as mimetics of the sialyltransfer by trypanosomal sialidases
journal contributionposted on 2023-06-07, 23:03 authored by Heike Busse, Mitsuru Hakoda, Matthew Stanley, Hansjorg Streicher
In an attempt to find competitive inhibitors of the trans- sialidase of the pathogen Trypanosoma cruzi, we have synthesized conjugates of carbocyclic sialylmimetics ( e. g., cyclohexenephosphonates) and galactose derivatives. A trans- sialidase inhibition assay revealed an interesting preference for ethylidene- spacered conjugates involving the 3- position of the sugar.
JournalJournal of Carbohydrate Chemistry
Department affiliated with
- Chemistry Publications
Full text available