PNAS-2012-Karmiloff-Smith-17261-5.pdf (127.27 kB)
Genetic and environmental vulnerabilities in children with neurodevelopmental disorders
journal contribution
posted on 2023-06-09, 02:20 authored by Annette Karmiloff-Smith, Dean D’Souza, Tessa M Dekker, Jo Van Herwegen, Fei Xu, Maja Rodic, Daniel AnsariOne might expect that children with varying genetic mutations or children raised in low socioeconomic status environments would display different deficits. Although this expectation may hold for phenotypic outcomes in older children and adults, cross-syndrome comparisons in infancy reveal many common neural and sociocognitive deficits. The challenge is to track dynamic trajectories over developmental time rather than focus on end states like in adult neuropsychological studies. We contrast the developmental and adult approaches with examples from the cognitive and social domains, and we conclude that static models of adult brain lesions cannot be used to account for the dynamics of change in genetic and environmentally induced disorders in children.
History
Publication status
- Published
File Version
- Accepted version
Journal
Proceedings of the National Academy of SciencesISSN
1091-6490Publisher
National Academy of SciencesExternal DOI
Issue
2Volume
109Page range
17261-17265Department affiliated with
- Psychology Publications
Full text available
- Yes
Peer reviewed?
- Yes