Lester_et_al-2016-American_Journal_of_Medical_Genetics_Part_B__Neuropsychiatric_Genetics.pdf (145.97 kB)
Genetic variation in the endocannabinoid system and response to cognitive behavior therapy for child anxiety disorders
journal contribution
posted on 2023-06-09, 02:30 authored by Kathryn LesterKathryn Lester, Jonathan R I Coleman, Susanna Roberts, Robert Keers, Gerome Breen, Susan Bögels, Cathy Creswell, Jennifer L Hudson, Anna McKinnon, Maaike Nauta, Ronald M Rapee, Silvia Schneider, Wendy K Silverman, Mikael Thastum, Polly Waite, Gro Janne H Wergeland, Thalia C EleyExtinction learning is an important mechanism in the successful psychological treatment of anxiety. Individual differences in response and relapse following Cognitive Behavior Therapy may in part be explained by variability in the ease with which fears are extinguished or the vulnerability of these fears to re-emerge. Given the role of the endocannabinoid system in fear extinction, this study investigates whether genetic variation in the endocannabinoid system explains individual differences in response to CBT. Children (N?=?1,309) with a primary anxiety disorder diagnosis were recruited. We investigated the relationship between variation in the CNR1, CNR2, and FAAH genes and change in primary anxiety disorder severity between pre- and post-treatment and during the follow-up period in the full sample and a subset with fear-based anxiety disorder diagnoses. Change in symptom severity during active treatment was nominally associated (P?
History
Publication status
- Published
File Version
- Published version
Journal
American Journal of Medical Genetics Part B: Neuropsychiatric GeneticsISSN
1552-4841Publisher
WileyExternal DOI
Issue
2Volume
174Page range
144-155Department affiliated with
- Psychology Publications
Full text available
- Yes
Peer reviewed?
- Yes
Legacy Posted Date
2016-08-11First Open Access (FOA) Date
2016-08-11First Compliant Deposit (FCD) Date
2016-08-11Usage metrics
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