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Genome-wide association analyses identifies a susceptibility locus for tuberculosis on chromosome 18q11.2
journal contributionposted on 2023-06-07, 16:05 authored by Thorsten Thye, Fredrik O. Vannberg, Sunny H. Wong, Ellis Owusu-Dabo, Ivy Osei, John Gyapong, Giorgio Sirugo, Fatou Sisay-Joof, Anthony Enimil, Margaret A. Chinbuah, Sian Floyd, David K. Warndorff, Lifted Sichali, Simon Malema, Amelia C. Crampin, Bagrey Ngwira, Yik Y. Teo, Kerrin Small, Kirk Rockett, Dominic Kwiatkowski, Paul E. Fine, Philip C. Hill, Melanie NewportMelanie Newport, Christian Lienhardt, Richard A. Adegbola, Tumani Corrah, Andreas Ziegler, Andrew P. Morris, Christian G. Meyer, Rolf D. Horstmann, Adrian V. S. Hill
We combined two tuberculosis genome-wide association studies from Ghana and The Gambia with subsequent replication in a combined 11,425 individuals. rs4331426, located in a gene-poor region on chromosome 18q11.2, was associated with disease (combined P = 6.8 x 10(-9), odds ratio = 1.19, 95% CI = 1.13-1.27). Our study demonstrates that genome-wide association studies can identify new susceptibility loci for infectious diseases, even in African populations, in which levels of linkage disequilibrium are particularly low.
PublisherNature Publishing Group
Department affiliated with
- Clinical and Experimental Medicine Publications
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