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Glucose-6-phosphate dehydrogenase status and risk of hemolysis in plasmodium falciparum-infected African children receiving single-dose primaquine

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posted on 2023-06-09, 17:05 authored by Chi EziefulaChi Eziefula, Helmi Pett, Lynn Grignard, Salome Opus, Moses Kiggundu, Moses R Kamya, Shunmay Yeung, Sarah G Staedke, Teun Bousema, Chris Drakeley
Glucose-6-phosphate dehydrogenase (G6PD) enzyme function and genotype were determined in Ugandan children with uncomplicated falciparum malaria enrolled in a primaquine trial after exclusion of severe G6PD deficiency by fluorescent spot test. G6PD A heterozygotes and hemizygotes/homozygotes experienced dose-dependent lower hemoglobin concentrations after treatment. No severe anemia was observed.

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Publication status

  • Published

File Version

  • Published version

Journal

Antimicrobial Agents and Chemotherapy

ISSN

0066-4804

Publisher

American Society for Microbiology

External DOI

Issue

8

Volume

58

Page range

4971-4973

Department affiliated with

  • Global Health and Infection Publications

Full text available

  • Yes

Peer reviewed?

  • Yes

Legacy Posted Date

2019-02-28

First Open Access (FOA) Date

2019-02-28

First Compliant Deposit (FCD) Date

2019-02-28

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    CC BY 4.0

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