posted on 2023-06-08, 14:41authored bySonya Newcombe, Mariusz Bobin, Amruta Shrikhande, Chris Gallop, Yannick Pace, Helen Yong, Rebecca Gates, Shuvashri Chaudhuri, Mark Roe, Eva Hoffmann, Eddy Viseux
Modular gold amide chemotherapeutics: Access to modern chemotherapeutics with robust and flexible synthetic routes that are amenable to extensive customisation is a key requirement in drug synthesis and discovery. A class of chiral gold amide complexes featuring amino acid derived ligands is reported herein. They all exhibit in vitro cytotoxicity against two slow growing breast cancer cell lines with limited toxicity towards normal epithelial cells.