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HTS approaches to voltage-gated ion channel drug discovery
journal contributionposted on 2023-06-08, 19:29 authored by Jane Denyer, Jennings Worley, Brian Cox, Gary Allenby, Martyn Banks
Voltage-gated ion channels are emerging as a target class of increasing importance to the pharmaceutical industry because of their relevance to a wide variety of diseases in the cardiovascular, CNS and metabolic areas. In the quest to identify novel lead molecules against these targets, drug discovery programmes are increasingly making use of HTS approaches. The authors describe the current technologies available for voltage-gated ion-channel screening, their application to HTS campaigns and the current limitations and emerging technologies within this area.
JournalDrug Discovery Today
Department affiliated with
- Chemistry Publications
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