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Harnessing cd8+cd28- regulatory t cells as a tool to treat autoimmune disease
journal contribution
posted on 2023-06-10, 03:42 authored by Sabrina Ceeraz, Charlie ThompsonCharlie Thompson, Richard Beatson, Ernest H ChoyT regulatory cell therapy presents a novel therapeutic strategy for patients with autoimmune diseases or who are undergoing transplantation. At present, the CD4+ Treg population has been extensively characterized, as a result of defined phenotypic and functional readouts. In this review article, we discuss the development and biology of CD8+ Tregs and their role in murine and human disease indications. A subset of CD8+ Tregs that lack the surface expression of CD28 (CD8+CD28- Treg) has proved efficacious in preclinical models. CD8+CD28- Tregs are present in healthy individuals, but their impaired functionality in disease renders them less effective in mediating immunosuppression. We primarily focus on harnessing CD8+ Treg cell therapy in the clinic to support current treatment for patients with autoimmune or inflammatory conditions.
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Publication status
- Published
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- Published version
Journal
CellsISSN
2073-4409Publisher
MDPIExternal DOI
Issue
11Volume
10Page range
1-11Article number
a2973Event location
SwitzerlandDepartment affiliated with
- Clinical and Experimental Medicine Publications
Full text available
- Yes
Peer reviewed?
- Yes
Legacy Posted Date
2022-05-27First Open Access (FOA) Date
2022-05-27First Compliant Deposit (FCD) Date
2022-05-27Usage metrics
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