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Health-related quality of life in people living with HIV with cognitive symptoms: assessing relevant domains and associations

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posted on 2023-06-10, 06:39 authored by Katie AlfordKatie Alford, Sube Banerjee, Stephanie DaleyStephanie Daley, Elizabeth Hamlyn, Daniel Trotman, Jaime Vera RojasJaime Vera Rojas
This study aimed to validate and assess a comprehensive set of illness-specific health-related quality of life (HRQL) domains in people living with HIV (PLWH) with cognitive symptoms. One hundred and three HIV patients with cognitive symptoms (n?=?93 male, 90.3%) were identified from two UK HIV clinics and complete a series of validated scales measuring seven HRQL domains identified as important to HRQL by PLWH with cognitive impairment. These included: physical functioning, cognition, social connectedness, self-concept, HIV stigma, acceptance of and perceived control over cognitive health, and physical and mental health and wellbeing. Exploratory factor analysis confirmed that domain total scores loaded onto one main factor, representing HRQL. Scale cut-off scores revealed a significant proportion of patients scored outside the normal range on single domains (between 26.2% and 79.6%), and many patients on multiple domains (40.8% on 4 or more domains). We found evidence of poor HRQL across domains in the majority of PLWH with cognitive symptoms and identified domains driving these experiences. This provides targets for intervention development and clinical action to maintain or improve HRQL in PLWH with cognitive symptoms or impairment.

History

Publication status

  • Published

File Version

  • Published version

Journal

Journal of the International Association of Providers of AIDS Care (JIAPAC)

ISSN

2325-9582

Publisher

SAGE Publications

Volume

22

Page range

23259582231164241

Event location

United States

Department affiliated with

  • Global Health and Infection Publications

Full text available

  • Yes

Peer reviewed?

  • Yes

Legacy Posted Date

2023-04-12

First Open Access (FOA) Date

2023-04-12

First Compliant Deposit (FCD) Date

2023-04-12

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