fmolb-08-647884.pdf (1.42 MB)
Hiding in plain sight: formation and function of stress granules during microbial infection of mammalian cells
journal contribution
posted on 2023-06-09, 23:45 authored by Alistair Tweedie, Tracy NissanStress granule (SG) formation is a host cell response to stress-induced translational repression. SGs assemble with RNA-binding proteins and translationally silent mRNA. SGs have been demonstrated to be both inhibitory to viruses, as well as being subverted for viral roles. In contrast, the function of SGs during non-viral microbial infections remains largely unexplored. A handful of microbial infections have been shown to result in host SG assembly. Nevertheless, a large body of evidence suggests SG formation in hosts is a widespread response to microbial infection. Diverse stresses caused by microbes and their products can activate the integrated stress response in order to inhibit translation initiation through phosphorylation of the eukaryotic translation initiation factor 2a (eIF2a). This translational response in other contexts results in SG assembly, suggesting that SG assembly can be a general phenomenon during microbial infection. This review explores evidence for host SG formation in response to bacterial, fungal, and protozoan infection and potential functions of SGs in the host and for adaptations of the pathogen.
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- Published
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- Published version
Journal
Frontiers in Molecular BiosciencesISSN
2296-889XPublisher
Frontiers MediaExternal DOI
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8Page range
173-173Article number
a647884Department affiliated with
- Biochemistry Publications
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- Yes
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- Yes
Legacy Posted Date
2021-04-30First Open Access (FOA) Date
2021-04-30First Compliant Deposit (FCD) Date
2021-04-29Usage metrics
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