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How telomerase reaches its end: mechanism of telomerase regulation by the telomeric complex.
journal contributionposted on 2023-06-07, 19:46 authored by Alessandro BianchiAlessandro Bianchi, D Shore
The telomerase enzyme, which synthesizes telomeric DNA repeats, is regulated in cis at individual chromosome ends by the telomeric protein/DNA complex in a manner dependent on telomere repeat-array length. A dynamic interplay between telomerase-inhibiting factors bound at duplex DNA repeats and telomerase-promoting ones bound at single-stranded terminal DNA overhangs appears to modulate telomerase activity and to be directly related to the transient deprotection of telomeres. We discuss recent advances on the mechanism of telomerase regulation at chromosome ends in both yeast and mammalian systems.
Department affiliated with
- Sussex Centre for Genome Damage Stability Publications
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